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Aspirin Cardio tablets 100mg #28

Aspirin Cardio tablets 100mg #28
Manufacturer: Germany
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Aspirin Cardio tablets 100mg #28

Indications related to inhibition of platelet aggregation: To reduce the risk of myocardial infarction in patients with unstable angina or in patients who have had a previous myocardial infarction. 
20 tablets 100 mg

Mode of action:
Mode of action of Aspirin Cardio manifest influence exerted acetylsalicylic acid ( the active ingredient ) in the body. Aspirin Cardio refers to a group of non-steroidal anti-inflammatory drugs ( NSAIDs). Its effects on the body due to the ability to block prostaglandinsintetazy - an enzyme involved in the biosynthesis of prostaglandins. Inhibiting the production of inflammatory hormones ( prostaglandin ) , Aspirin Cardio has analgesic , antipyretic , anti-inflammatory effect. Aspirin Cardio retards aggregation ( clumping ) and adhesive properties of platelets. This is due to inhibition of the biosynthesis of thromboxane A2 in platelets . After receiving Aspirin Cardio , antiplatelet effect is detected during the week ( less pronounced in women than in men) .
When exceeding a daily dose of aspirin Cardio than 6 g, marked inhibition of the biosynthesis of prothrombin into hepatocytes in vitro prothrombin time lengthens .
Aspirin Cardio markedly increases the ability of plasma fibrinolysis and to reduce the specific amount of 10, 9 , 7, 2 coagulation factors which are also called vitamin K- dependent. Analgesic effect is not expressed clearly , and due to lower susceptibility of the nerve cells to the factors of irritation by reducing the total number of inflammatory mediators that act native irritation.

Aspirin is rapidly and almost completely absorbed after oral administration . Food slows down , but does not reduce the absorption of Aspirin Cardio . Enteric-coated dosage forms of the drug prevents the release of acetylsalicylic acid in the stomach. This process takes place in an alkaline environment of the duodenum and small intestine . Therefore , Aspirin Cardio soaked for 2-5 hours later , compared with a conventional acetylsalicylic acid. Deacetylation 50% acetylsalicylic acid is in the hepatocytes , while passing from the intestine through the liver. Metabolic products of acetylsalicylic , salicylic acid is salicylic acid and glitsinkonyugaty glitsinkonyugat gentisic acid. They are distinguished by the kidneys as metabolites . The half-life is directly proportional to the amount of acetylsalicylic acid , and begins 20 minutes after reaching the maximum concentration in plasma. In newborn infants, the excretion of aspirin occurs more slowly than in the adult organism . Aspirin Cardio easily penetrates through the natural barriers in the body. It is found in the spinal fluid of the joint cavity , the fetal blood and breast milk.

Indications for use :
Indications for Use of Aspirin Cardio apply to all diseases for which there is an excess risk of thrombosis or .
Aspirin Cardio used as antiplatelet drug therapy in almost all forms of ischemic heart disease, prevention of coronary heart disease (with risk factors ) , unstable and stable angina pectoris, myocardial infarction ( prevention of thrombotic complications) , operations on the heart and blood vessels .
In neurological practice in transient cerebral blood flow, cerebral ischemia . In cases of venous thrombophlebitis of the lower limbs (prevention of thromboembolism ) , recurrent pulmonary embolism , pulmonary infarction .

How to use:
Aspirin Cardio is taken before a meal without chewing, drinking plenty of fluids . Aspirin Cardio take once in 1-2 days. Long course of treatment , established by the attending physician.
The usual dosage is from 0.1 to 0.3 g / day. Typically, the first prescribed Aspirin 0.3g Cardio night . After a therapeutic effect , confirmed by coagulation tests , switching to maintenance therapy - 0.1 g per day.

Side effects:
Government gastrointestinal tract ( GIT) . There have pain, swelling , pain, spasmodic character, chair disorders , peptic ulcer (very rare), appetite loss , hepatitis , pancreatitis .
The nervous system . Rarely observed symptoms of dizziness and headache.
Skin. Rare are itching , hives , dermatitis , thrombocytopenic purpura.
Genito-urinary system . Rarely observed symptoms of decline of renal excretory function .
Hematopoietic organs and circulatory system . Rare are anemia, leukopenia, eozinofilliya , thrombocytopenia , agranulocytosis . When receiving Aspirin Cardio there is an increased risk of bleeding due to the shift of the coagulation of the blood - antisertyvayuschey aside antisvertyvaniya . Possible nasal , hemorrhoids , esophageal , gastrointestinal and other bleeding.
The respiratory system. Subject to contra rare bronchospasm , laryngeal edema , cough .
Subject to contra anaphylactic reactions are rare.

Contraindications:
Individual intolerance of aspirin and other NSAIDs Cardio , thrombocytopenia, asthma and aspirin triad of coagulopathy ( hemophilia , hemorrhagic diathesis , and others) , thrombocytopenic purpura , gastric ulcer , duodenal ulcer ( exacerbation or bleeding) , portal cirrhosis of the liver, 1 and 3 trimesters of pregnancy, breast-feeding , liver failure and kidney failure, age younger than 15 years.
With careful use of Aspirin Cardio in patients with stone disease , bronchial asthma , alcoholism, gout , hepatitis , hyperuricemia , peptic ulcer and duodenal ulcer ( remission) , in the 2nd trimester of pregnancy.

Pregnancy :
It is better to refrain from taking Aspirin Cardio during pregnancy because it can easily cross the placental barrier. At 1 and 3 trimester contra categorical. In the 2nd trimester should be weighed against the value of the expected therapeutic effect, with the risk of fetal malformations .
During lactation Aspirin Cardio contraindicated .

Interactions with other drugs:
Not recommended for concomitant use of aspirin and other NSAIDs Cardio ( salicylates and pyrazolone ), because it causes a potentiation of side effects and reduced therapeutic efficacy. Co-administration of an anticoagulant with direct (heparin ) and the indirect action, increases the risk of hemorrhage .
Aspirin Cardio increases the number of lithium ions in the blood, concurrent therapy with metal salts . 2-3 days during coadministration with digoxin , increases in plasma levels of the glycoside . After the abolition of Aspirin Cardio concentration of digoxin in the blood to normal no earlier than 48 hours
Aspirin Cardio promotes water and sodium retention in the body , reducing the therapeutic effect of diuretics and antihypertensives . Co-administration of cyclosporin with antibiotics increases the number of nephrotoxic effect. Glucocorticoids increase the toxicity of Aspirin Cardio . Between doses of methotrexate and Aspirin Cardio needed a break for 24 hours in order to avoid an increase in the toxicity of the drug.

Overdose:
Are three degrees of severity of the overdose .
The first degree occurs when a single dose of Aspirin Cardio less than 0.15 g / kg of patient weight . Symptoms : dyspepsia , headache, vision disturbances , fever . The second stage occurs when a single dose of aspirin Cardio from 0.15 to 0.3 g / kg of patient weight , and the third in the case of coupon more than 0.3 g / kg.
If poisoning is used gastric lavage and oral sorbents, laxatives, symptomatic treatment . Necessary to control the pH of the blood and the introduction of sodium bicarbonate in cases of displacement of homeostasis in the acidic side . Hemodialysis and mechanical ventilation is used in severe cases , according to testimony .

Product:
Tablets, enteric coated 0.1 g, in a blister pack , № 20.
Tablets, enteric coated 0.3 g, in a blister pack , № 20.

Storage:
Aspirin Cardio is kept at a temperature not exceeding 25 degrees Celsius in the reach of children.

Synonyms:
Aspro , Aspirin, acetylsalicylic acid, Atsekardin , Polokard .

Ingredients:
One tablet of Aspirin Cardio contains acetylsalicylic acid ( the active ingredient ) 0.1 or 0.3 , the
Excipients: talc, corn starch , cellulose, methacrylic acid and acrylic acid ethyl ester , sodium lauryl sulfate, polysorbate 80, triethyl citrate .

In addition:
During treatment with Aspirin Cardio in patients with chronic liver disease and kidney failure, recommended laboratory monitoring function of these organs . Control of coagulation parameters is shown in the cases of violation of the coagulation of the blood - antisvertyvayuschey . The presence of fecal occult blood is carried to patients who had a history of ulcerative lesions of the stomach and duodenum.
The course of treatment Aspirin Cardio long . Doctor set the dosage and duration of use. You should not take Aspirin Cardio own. Antisvertyvayuschey Aspirin Cardio activity persists for several days after discontinuation of the drug , which should be considered in the surgical treatment . Older people are more sensitive to a drug overdose .
Cardio Aspirin has no effect on the concentration and attention.

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