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Essentiale N ampoules 5ml #5

Essentiale N ampoules 5ml #5
Essentiale N ampoules 5ml #5 Essentiale N ampoules 5ml #5 Essentiale N ampoules 5ml #5 Essentiale N ampoules 5ml #5
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Manufacturer: Germany / Ukraine
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Essentiale N ampoules 5ml #5

Essentiale N 5ml ampoules, 5 ampoules per box.
New design of box, please see additional picres.

Mode of action:
The active ingredient in the so-called essential phospholipids (EPL-substance), which are highly purified fraction of phosphatidylcholine. Essential phospholipids in their chemical structure similar to endogenous membrane phospholipids, exceeding them by their functional properties due to the high content of polyunsaturated fatty acids, especially linoleic acid. Phospholipids are the basic building blocks of cell membranes and organel. They are involved in differentiation, division and cell regeneration.
 
The functional significance of phospholipids based on their amphiphilic properties, which allow you to adjust the permeability of cell membranes. They improve the function of membranes, in particular, ion exchange, the process of intracellular respiration, biological oxidation, affect the binding of intracellular enzymes of respiration in mitochondria, as well as on the process of oxidative phosphorylation in energy metabolism of cells. Under physiological conditions, the synthesis of phospholipids meets the needs of normal hepatocytes, which contain a sufficient number of phospholipids. It is known that the structure of cell membranes and the function of enzyme systems in liver disease are violated. Disturbed biosynthesis of phospholipids, the deficit which leads to disruption of cell membrane function. These processes are particularly pronounced in the mitochondria, which are approximately 30% are composed of phospholipids and that made the most important metabolic processes including oxidative phosphorylation. With a deficit of phospholipids is a violation of lipid metabolism, which leads to fatty liver. Due to its pharmacological properties Essentiale eliminate the violations, promotes regeneration of cell membranes, membrane-bound enzyme activates the broken system and receptors, increases the ability of the liver detoxification and thereby normalize its function.
 
Pharmacokinetics
The half-life for the choline component is 66 hours, for saturated fatty acids - 32 hours.
In studies on the pharmacokinetics in humans of less than 5% of each of the introduced isotopes 3H and 14C excreted in faeces.
 
Indications for use:
Fatty degeneration of the liver (as in diabetes), acute and chronic hepatitis, cirrhosis, liver cell necrosis, hepatic coma and precoma, toxic liver damage, including toxaemia of pregnancy, pre-and post-operative treatment, especially for operations in the field of hepatobiliary zone, psoriasis, neurodermatitis , the radiation syndrome.
 
Method of application:
Capsules: In the absence of the doctor's recommendations, the initial dose: 2 capsules 3 times daily, maintenance dose: 1 capsule 3 times a day. Taking capsules during a meal, without chewing, with a little water.
Intravenous injection: Adults and children administered by slow intravenous injection of 5-10 ml per day, and in severe cases - from 10 to 20 ml per day. For once allowed to enter up to 10 ml of the drug. If the drug is administered diluted, it is recommended to use the patient's own blood, and introduced the drug in a 1:1 ratio. Intravenous injection is usually used within 10 days. It is recommended as early as possible to maintain (add) parenteral therapy capsules Essentiale (Essentiale Forte N).
 
The total course of treatment is 3-6 months.
Treatment of psoriasis begin with the appointment of the drug to 2 capsules 3 times daily for 2 weeks, then make a 10 intravenous injections of 5 ml of the drug with the simultaneous appointment of PUVA-therapy.
After completing the course of injections to resume taking the drug in and continue it for 2 months.
 
Side effects:
Very rarely in higher doses may be Essentiale gastrointestinal upset (diarrhea).
 
Contraindications:
Do not administer in case of hypersensitivity to any component.
Solution for intravenous injection should not be administered to newborns and premature babies, as a part of this form of drug release is benzyl alcohol.
 
Pregnancy:
Can be used during pregnancy and lactation, but only on the advice of a doctor!
 
Interactions with other drugs:
So far, unknown.
For the dilution of the solution for intravenous administration should not be used electrolyte solutions.
 
Overdose:
There were no reports of overdose have been reported.
 
Product:
Ampoules of 5 ml of 5 pieces per pack.
 
Storage:
Shelf life 3 years. Capsules stored at temperatures not exceeding 25 ° C and the ampoule at a temperature of between +2 ° C to 8 ° C, in a dry place inaccessible to children.
 
Synonyms:
Essentiale Forte (Essentiale Forte), Essentiale Forte N (Essentiale Forte N), N Essentiale (Essentiale N)
 
Ingredients:
1 ampoule of 5 ml Essentiale (Essentiale N) contains:
The active ingredient is "essential phospholipids" = EFL-Essence (diglitseridnye acid esters holinfosfornoy natural origin, with a high content of unsaturated fatty acids, primarily linoleic (70%), linolenic and oleic acid) - 250 mg.
Other ingredients: benzyl alcohol, acid dizoksiholevaya, sodium chloride, sodium hydroxide, dye - riboflavin, water for injections.
 
In addition:
At a dilution of the solution Essentiale (Essentiale N) for solution for injection (in case you can not use the patient's own blood) should be applied solutions, free from electrolytes, namely, 5% or 10% glucose solution (in a ratio of 1:1) 5% solution of xylitol.
Not allowed to enter the drug intramuscularly, as you may experience local irritation.

Shipping condition:
Before shipping Essentiale is covered with a aluminium film and soft packing film to prevent thermal and shocking issues.

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