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Heptral for injections vials 400mg #5

Heptral for injections vials 400mg #5
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Manufacturer: Germany
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Heptral for injections vials 400mg #5

Heptral for injections vials 400mg #5 pharmachologic effect:
Geptral belongs to a group with hepatic antidepressant activity. It has choleretic and holekeneticheskoe action has detoxifying, regenerating, antioxidant, antifibrinolytic and neuroprotective properties. The drug not only makes up for lack of ademetionine in the body, but also promotes its products in various organs (especially the liver, brain and spinal cord). Ademethionine substance that occurs in almost all tissues and body fluids. Because of its chemical structure, the drug is a methyl group donor in the transmethylation reactions. Is the basis for many biochemical thiol compounds (cysteine, taurine, coenzyme A, etc.) During transsulfuration, a precursor of polyamines (putrescine, spermidine, spermine, within the structure of the ribosome), stimulates cell regeneration.

Transmethylation (transfer methyl groups) ademetionine to various substances in the body (hormones, neurotransmitters, proteins, phospholipids) is an important metabolic processes.
When observed increase in long-term use of glutamine in the liver, taurine and cysteine ​​in plasma, reducing the number of methionine in serum, suggesting that the normalization of metabolic processes in the liver and an improvement in its function.
The drug has choleretic effect by stimulating the synthesis of phosphatidylcholine in the membranes of hepatocytes and to increase their flexibility and polarization. This leads to improvement in function bile acid transport systems and promotes the release of bile acids in the biliary system. The drug promotes detoxification of bile acids through their sulfation. What contributes to their elimination by the kidneys, it facilitates the passage through the membrane of hepatocytes and excretion of bile. Before the drug is observed positive dynamics of the level of direct bilirubin, alkaline phosphatase activity, aminotranferaz. Choleretic and hepatoprotective persists for 3 months after stopping treatment.

Ademetionine content in the body of children and adolescents are significantly higher than in the elderly, as with age, its level decreases. Also, the level of ademetionine lower in people suffering from depressive syndrome. Ademetionine large concentration in the brain contributes to the metabolism of catecholamines (epinephrine, norepinephrine), indolamine (serotonin, melatonin) and histamine. The drug normalizes the methylation of phospholipids in the membranes of nerve cells, stabilizing the transmission of nerve impulses and extend the functioning of nerve cells. Experimentally proven efficacy in the treatment of Geptral depression. Antidepressant effects develops rapidly and reaches peak efficiency at 5-7 days of treatment. Before the drug Geptral ademetionine goes through the same stages of transformation that endogenous substances.

Indications:
  • Intrahepatic cholestasis (impaired synthesis and bile flow);
  • Liver disease, including chronic acalculous cholecystitis, cholangitis;
  • Cirrhotic and pretsirroticheskie state;
  • Toxic liver disease, including viral, alcohol, drugs (antibiotics, chemotherapy, anti, anti-viral agents, contraceptives);
  • Fatty liver, chronic hepatitis;
  • Depression;
  • Withdrawal symptoms, including alcohol.

Heptral for injections vials 400mg #5 mode of application:
The preparation is used for oral administration (film-coated tablets) for administration and / or m / in (lyophilized powder which is dissolved enclosed L-lysine solution immediately before administration). B / injected very slowly.
When intensive care injecting drug prescribed daily dose of 400-800mg (1-2 bottles) for the first 2-3 weeks of treatment.
For maintenance therapy drug is administered orally in a daily dose 0,8-1,6g (2-4 tablets). The drug is recommended to take between meals, preferably in the morning, as the use of the drug may cause some jitters. Tablets are washed down with a necessary amount of water, swallow without chewing. Maintenance therapy prescribed by the doctor (on average 2-8 weeks).

Heptral for injections vials 400mg #5 side effects:
From the gastrointestinal tract: nausea, gastralgia, dyspepsia, heartburn;
CNS: you can change the rhythm of sleep, for the correction of possible sedation at night;
Allergic reactions.

Heptral for injections vials 400mg #5 contraindications:
Increased individual sensitivity to the drug.

Heptral for injections vials 400mg #5 during pregnancy:
Do not use this in I and II trimester of pregnancy, in the last trimester use of the drug is possible if the expected benefit to the mother is higher than the potential risk to the fetus. During lactation, if necessary, taking the medication need to consider the issue of termination of breastfeeding.

Heptral for injections vials 400mg #5 overdose:
Posts Geptral drug overdose has been reported.

Heptral for injections vials 400mg #5 product form:
Lyophilized powder for solution for injection in vials 5ml of 5 pieces. together with the solvent.

Heptral for injections vials 400mg #5 storage conditions:
The drug should be stored in a dry place at temperatures no higher than 25 degrees Celsius.
Shelf life - 3 years.

Heptral for injections vials 400mg #5 composition:
Vials with powder for solution for injection 1 vial contains:
Ademetionine - 400 mg;
Solvent:
L-lysine salt buffer solution of caustic - 5ml.

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