Therapeutic category :Anti-allergic agent
Blocker of histamine H1-receptors. Has anti-allergic effect.
The drug does not cause strong anticholinergic and sedative effects. There was no action Kestin QT interval on the ECG (electro-cardiogram), even when used in a dose of 80 mg.
If ingestion expressed anti-allergic effect develops after 1:00 and lasts for 48 hours after a 5-day course of treatment Kestin antihistaminic activity is maintained for 72 hours due to the action of active metabolites.
The interaction with the body of the drug Kestin (kestine)
Penetration and distribution of the drug
When administered ebastine is rapidly absorbed from the gastrointestinal tract and nearly completely converted in the liver to the active metabolite carebastine. After a single dose of the drug at a dose of 10 milligrams carebastine Cmax in plasma is reached after 2.6-4 hours and is 80-100 ng / ml.
The daily dose of the drug at a dose of 10 milligrams Css achieved after 3-5 days of 130-160 ng / ml.
Interaction with plasma protein and carebastine ebastine is more than 95%
When taking the drug with meals simultaneously carebastine level in blood increases in 1.6-2 times, but it does not change the time to reach Cmax metabolite and has no effect on the clinical effects Kestin.
Metabolism and excretion of T1 / 2 carebastine is between 15 and 19 hours 66% of the active substance is in the form of conjugates in urine.
Pharmacokinetics in clinical cases
In elderly patients the pharmacokinetic parameters did not significantly change.
In patients with impaired renal function, T1 / 2 increases up to 23-26 hours, and with abnormal liver function - up to 27 hours
The use of drugs Kestin (kestine)
* Allergic rhinitis (seasonal and / or year-round);
* Idiopathic chronic urticaria (hives).
Dosage and how to use medicines Kestin (kestine)
Adults with allergic rhinitis Kestin prescribed a daily dose of 10 milligrams, with severe symptoms (such as at the year-round allergic rhinitis) - 20 mg.
In idiopathic chronic urticaria daily dose is 10 milligrams.
The drug is taken one time a day, regardless of meals.
Side effects while taking Kestin (kestine)
From the CNS (central nervous system) may headache, drowsiness, rarely - asthenia (weakness), and insomnia.
Digestive system: dry mouth, rarely - abdominal pain, dyspepsia (violation of gastric digestion), nausea (vomiting).
Other reactions and symptoms: rarely - rhinitis, sinusitis.
Contraindications Kestin (kestine)
* Lactation (breastfeeding);
* Increased susceptibility to the drug.
The use of drugs in pregnancy and breastfeeding
Kestin is contraindicated during pregnancy because of the lack of reliable clinical data to support the safe use of the drug in pregnant women.
When you receive Kestin in feeding should decide on the termination of breastfeeding, due to the lack of data on the allocation of the active substance in breast milk.
Specific recommendations while taking the drug Kestin (kestine)
With extreme caution Kestin prescribed to patients with severe hepatic impairment and / or kidneys.
Do not appoint Kestin simultaneously with ketoconazole and erythromycin.
The use of child therapy
Clinical data on the effectiveness and safety of Kestin in children under the age of 12 years is not enough, so the question of the appointment of Kestin should be decided individually.
The impact on the ability to drive vehicles and management mechanisms
The drug does not affect the ability of patients to engage in potentially hazardous activities that require attention and psychomotor speed of reaction.
Exceeding the recommended dose of the drug Kestin (kestine)
Treatment: No specific antidote exists. Recommend gastric lavage, medical supervision and, if necessary, symptomatic treatment.
Drug interaction Kestin (kestine)
There were no clinically significant drug interactions with theophylline Kestin, indirect anticoagulants, cimetidine, diazepam, ethanol and ethanol-containing drugs.
Maximum date of the use and storage regulations Kestin (kestine)
The drug should be stored in the dark of night light at a temperature from 15 ° to 30 ° C. Maximum date of service - 3 years.