Noofen (Phenibut) is the drug that combines all these properties. It ameliorates memory, intellectual activity, enhances brain resistance to harmful effects.
Phenibut - is a derivative of GABA and phenylethylamine, it is used as antihypoxant antianamnesticheskoe and as a means. The drug has anxiolytic properties, reduces the severity of cognitive disorders, manifestations of anxiety and fear, normalizes sleep, and improves physical and mental performance, has anticonvulsant properties. Patients with fatigue, medication improves performance without causing side effects such as agitation or irritability. Effective for the treatment of patients with vazovegetativnymi symptoms such as headache, sleep disturbances, frequent mood swings, dizziness. Unlike tranquilizers not impair attention and memory speed psychic reactions. In addition, the drug increases the number of mitochondria and lipid peroxidation, which is especially important when administered to patients with head injury or comorbidities (diseases of the cardiovascular system, gastrointestinal pathology).
The drug potentiates the effects of sleeping pills, tranquilizers, anticonvulsants and antipsychotics, while not affecting the adrenergic and cholinergic receptors.
The drug is well and completely absorbed from the gastrointestinal tract, penetrate the BBB. Withdrawal of the drug gradually, mainly through the kidneys. Cumulation is not observed with repeated administration.
Indications for use:
- Trevozhno- neurotic condition;
- Nervous disorders in children: enuresis, stuttering, tics;
- Senile disorders: insomnia in the elderly, anxiety syndromes;
- Before surgery or complex diagnostic procedures, to reduce the severity of anxiety and stress;
- Alcoholism and withdrawal states (including delirium and preddelirioznye state);
- Meniere's disease;
- Pathology of the vestibular apparatus;
- Pathological menopause;
- In the complex therapy treatment of osteoarthritis in women;
- Cognitive disorders, memory disorders.
Method of application:
The average therapeutic dosage for adults 0.25-0.5 g three times a day, if necessary, the dose may be increased to 2.5, the highest dose at one time is not more than 0.75 g for patients over 60 years of not more than 0.5 grams
Children of drug prescribed according to age:
· 3 to 4 years of 0.1 g twice a day, the highest dose of single dose of 0.1 g;
· From 5 to 6 years 0.1 g 2-3 times a day, the highest dose of single dose of 0.1 g;
· 7 to 10 years of 0.1 g of 3- 4raza day, the highest dose of single dose of 0.2 g;
· 11 to 14 years: 0.2 g of 2 -3 times a day, the highest dose at one time, 0.3 g;
· 14 years after the drug is given in a dosage as for adults.
While appointing Noofen with other psychotropic drugs, the dose can be reduced, as there is a mutual potentiation of effects.
For the treatment of alcoholism and withdrawal syndrome Noofen assigned as follows: 0.25 - 0.5 g of 3 times during the day and at night and 0.75 g of this scheme is applied for several days, then the patient is gradually transferred to the usual adult dosage.
To reduce the severity or eliminate vertigo (Meniere's syndrome, labyrinthitis otogenny other pathology of the vestibular apparatus) Noofen appoint 0.75 g three times a day, for a week, then at 0.25 - 0.5 three times a day for a week, then once at 0.25 per day for 5 days. If symptoms mild and the disease is easily enough, perhaps use of the drug by 0.25 g twice a day for a week, then 0.25 g once, for 7-10 days.
If vestibular disorders are vascular or traumatic origin, Noofen appoint 0.25 g three times a day, for 12 days.
For the prevention of motion sickness, Noofen appoint 0.25 g -0.5 g, 1 hour before the voyage. At the onset of symptoms of seasickness, vomiting, drooling, use of the drug is ineffective.
To prevent air sickness, Noofen prescribe a dose of 0.25-0.5 g, 1 hour before the flight.
For the treatment of pathological menopause and osteochondrosis of the cervical-thoracic spine in women Noofen administered in a dose of 0.75 g per day, divided into 3 doses, for 14 days; then at 0.5 grams per day, divided into 2 doses for 14 days. With mild pain may Noofen appointment at a dose of 0.5 g per day, divided into 2 doses.
Very rarely, drowsiness and nausea, which usually occur after the first dose and tested independently.
Allergy to the active ingredient of the drug or its auxiliary components.
Pregnancy is a relative contraindication to Noofen, since there is no convincing evidence to support its safety.
Interaction with other drugs:
Perhaps the appointment Noofen, in combination with other drugs, including psychotropic drugs. When concomitant administration with tranquilizers, hypnotics, neuroleptics, mutual strengthening effect.
Only a significant excess of the daily dosage of the drug (7-14 g reception, for a long time) can lead to hepatotoxicity.
Symptoms of overdose include nausea, signs of liver failure, hypotension, drowsiness. Treatment: gastric lavage, the appointment of sorbents simtomaticheskoe treatment.
Tablets 0.25g each, 20 tablets.
Store in a cool, dry place at room temperature.
Active ingredient: Phenibutum 0.25 g.
Additional substances: lactose, potato starch, stearate, Ca.
Noofen irritates the mucous membrane of the digestive tract, so patients with pathology of the gastrointestinal tract, should be appointed in reduced doses.
With prolonged use requires monitoring of blood count and transaminases.
With care given to people whose work is related to the complex mechanisms and requires the speed of mental reactions.