Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body.
Who should use acetylsalicylic acid?
Rheumatism, rheumatoid arthritis, an infectious-allergic myocarditis, pericarditis.
Febrile syndrome in infectious and inflammatory diseases.
Pain syndrome (different backgrounds): headache (including associated with alcohol withdrawal syndrome), migraine, toothache, neuralgia, lumbago, thoracic radicular syndrome, myalgia, arthralgia.
How antiagregatnoe agent (doses up to 250 mg): Coronary heart disease, multiple risk factors for coronary heart disease, a painless myocardial ischemia, unstable angina, myocardial infarction (to reduce the risk of another heart attack and death after myocardial infarction), repeated transient cerebral ischemia and ischemic stroke in the marital, prosthetic heart valves (the prevention and treatment of venous thromboembolism), balloon angioplasty and coronary stent (reducing the risk of re-stenosis and the treatment of secondary stratification of coronary artery), at neateroskleroticheskih lesions of coronary artery disease (Kawasaki), aortoarteriit (Takayasu's disease), mitral valve heart defects and a flashing fibrillation, mitral valve prolapse (prevention of thrombosis), recurrent pulmonary embolism, pulmonary infarction, acute thrombophlebitis, Dressler's syndrome. In clinical immunology and allergy: a gradually increasing doses for a prolonged desensitization and the formation of stable tolerance to drugs of acetylsalicylic acid in patients with asthma, "triad", which are aggravated by the adoption of acetylsalicylic acid.
How to use acetylsalicylic acid?
The drug is taken orally after meal.
When fever and pain for adults - 500-1000 mg 3-4 times a day. The daily dose should not exceed 3 g. The duration of treatment should not exceed 2 weeks.
To improve the rheological properties of blood - 250 mg / day for several months.
Myocardial infarction, as well as for secondary prevention in patients who had suffered a heart attack - 250 mg 1 time per day.
As an inhibitor of platelet aggregation - 250 mg / day for a long time.
At the dynamic cerebral circulatory disorders, cerebral embolism - 250 mg / day with gradual increase in dose up to a maximum 1000mg/sut for relapse prevention - 250 mg / day.
Children - 50-200 mg 3-4 times a day, a single dose for children from 2 years - 100 mg, 3 years - 150 mg, 4 years - 200 mg, ranging from 5 years old - 250 mg daily dose - at the rate of 200 mg for 1 year of life.
Patients with functional deficiency of liver and kidney dose necessary to reduce or increase the interval between doses.
Since acetylsalicylic acid-Darnitsa, like all non-selective non-steroidal anti-inflammatory drugs, provoke irritation of the gastrointestinal tract, the drug should be taken only after meals, drinking water, alkaline mineral water, sodium bicarbonate (best of all - the milk).
In long-term use of aspirin-Darnitsa to check for blood in stool for detection of ulcerogenic effect and do blood tests (effects on platelet aggregation, a antikoaguliruyuschaya activity).
Children and adolescents with hyperthermia drug is desirable to appoint only if other analgesics-antipyretics. If in such patients because the drug vomiting occurs, it should be suspected Reye's syndrome. With careful use of medication for the treatment of patients with allergic rhinitis, nasal polyps, urticaria.
Before the scheduled surgical interventions to stop taking the drug for 5-7sutok before surgery.
Adverse effects of acetylsalicylic acid.
Acetylsalicylic acid-Darnitsa hypersensitivity to the drug can cause allergic reactions, urticaria, angioedema, various ekzantem, eosinophilia, bronchospasm. Hypersensitivity to the drug may develop anaphylaxis, asthma, bronchial asthma observed acceleration and intensification of attacks. With long-term treatment may develop ototoxic, nephrotoxic and hepatotoxic effects. When administered medication detects specific ulcerogenic effect, triggered by erosion and ulcers of the mucous membrane of the stomach and duodenal ulcers, gastro-intestinal bleeding. In very rare cases can gepatogennaya encephalopathy. Asthma triad (eosinophilic rhinitis, recurrent polyposis of the nose, hyperplastic sinusitis), aseptic meningitis, increased symptoms of congestive heart failure, edema, vomiting, nausea, thrombocytopenia, anemia, leukopenia.
Who should not acetylsalicylic acid?
Hypersensitivity to acetylsalicylic acid and ingredients. Acetylsalicylic acid-Darnitsa contraindicated in gastric ulcer and duodenal ulcer (including history), gastritis with hyperacidity, gastrointestinal bleeding, portal hypertension, venous stasis, in the first 3 months of pregnancy and women who breastfeed.
Asthma expressed human liver and kidney, chronic or recurrent dyspepsia.
The interaction of acetylsalicylic acid.
The drug increases the action of anticoagulants, sulfonylurea derivatives saharoponizhayuschih. Reduces the effectiveness of spironolactone, furosemide, antihypertensives.
Increases the side effects of corticosteroids, methotrexate.
Caffeine and metoklopiramid enhance absorption of acetylsalicylic acid in the gastrointestinal tract.
Aspirin blocks the gastric alcohol dehydrogenases than increases the level of ethanol in the body.
An overdose of aspirin.
In mild form of intoxication on the severity of potential drug: nausea, vomiting, pain in the epigastric region, dizziness, tinnitus, headache. In severe cases - confusion, tremor, dyspnea, metabolic acidosis, coma, collapse. Possible lethal dose: adults, above 10 grams for children - above 3 g.
Treatment. Correction of acid-base balance, fluid and electrolyte balance, infusion of sodium bicarbonate, sodium lactate.