Milgamma pharmachologic effect:
The structure includes milgamma neurotropic B vitamins in therapeutic doses used in diseases of the nerves and nervous tissue, accompanied by inflammatory and degenerative processes and \ or violation of nerve conduction. Also used in the pathology of the musculoskeletal system. B vitamins in high doses promote pain relief, improve microcirculation, stabilize the nervous system, improve the processes of hematopoiesis.
Vitamin B1 (thiamine) is metabolized in the body kokarboksilazu (tiamindifosfata) and thiamine triphosphate by phosphorylation. Kokarboksilazu coenzyme as an enzyme involved in the chain of carbohydrate metabolism, which is important for the normal functioning of nerves and nerve tissue. It enhances conduction in nerves by affecting synaptic transmission. Deficiency of vitamin B1 (thiamine) is accompanied by the accumulation in tissues oxidized carbohydrate metabolism products: pyruvic acid, lactic acid. As a result, there is a malfunction of the nervous tissue with the formation of various pathological conditions.
In tablets milgamma thiamine chloride is replaced by benfotiamine, is fat-soluble derivative of thiamine. Benfotiamine is metabolized by phosphorylation in tiaminpiruvat and thiamine triphosphate - biologically active substances. Role of thiamine is involvement of carbohydrate metabolism (as a coenzyme pyruvate decarboxylase enzymes transketolase). Tiaminpiruvat carries aldehyde groups in the pentose phosphate cycle.
Vitamin B6 (pyridoxine) is phosphorylated in the body tissues. The metabolic products are co-enzymes non-oxidative metabolism of almost all amino acids. Coenzymes involving decarboxylation of amino acids to form many physiologically active mediators - epinephrine, tyramine, dopamine, histamine, serotonin. Also involved in catabolism and anabolism of amino acids by transamination processes. Vitamin B6 affects the metabolism of tryptophan, under its influence catalysis occurs α-amino-β-ketoadininovoy gemoglobinoobrazovaniya acid process.
Vitamin B 12 (cyanocobalamin) has protivoanemicheskim action, promotes the synthesis of creatinine, choline, nucleic acids methionine. Participates in the processes of cellular metabolism. It is analgesic.
Vitamin B1 (thiamine) is dephosphorylated in the renal tissue. The half-life is 35 minutes. In the tissues of the body does not accumulate because of almost complete insolubility in fats. The metabolic products are excreted in the urine.
Pyridoxine (vitamin B 6) after phosphorylation converted into pyridoxal-5-phosphate. After entering the last blood plasma bound to albumin. Alkaline phosphatase hydrolyzes pyridoxal-5-phosphate, whereupon this metabolite may hit the cell.
Cyanocobalamin (Vitamin B12) if it enters the blood plasma is bound to proteins to form transport complex. As such, its absorption occurs hepatic tissue. Cyanocobalamin also accumulate in the bone marrow, pass through the blood-barrier. After isolating the bile into the intestine can be absorbed again (enterohepatic circulation).
Milgamma - Indications for use:
The need for a tonic effect;
Polyneuropathy of various origins (alcohol, diabetogenic);
Herpes zoster and other manifestations of herpesvirus infections;
Paresis of the facial nerve.
Milgamma - Mode of application:
Treatment started with 2 ml intramuscularly milgamma (very deep into the muscle) 1 time per day. Supportive therapy - milgamma 2 ml 2-3 times a week. Or perhaps further treatment oral formulation (1 tablet per day). For fast relief of pain is applied parenteral form milgamma or tablets up to 3 per day (1 tablet). When used polyneuropathies dose of 1 tablet 3 p / p. The duration of treatment is 1 month.
Systemic reactions (sweating, decrease in heart rate, arrhythmia, dizziness, nausea, convulsions). Systemic reactions occur during administration of the drug very quickly, or in case of exceeding the dosage.
Heart failure (acute or severe chronic decompensated heart failure);
Violation of the conduction of the heart muscle;
Hypersensitivity to milgamma components;
The age of 16 years.
Milgamma during pregnancy:
Milgamma not applied during pregnancy and lactation, as research on the influence of pregnancy and penetration in breast milk have not been conducted.
Milgamma - interaction with other drugs:
When mixed with sulphate solution Vitamin B1 dissolves completely. Given the presence of the products of metabolism are inactivated thiamine other vitamins. Thiamine (benfotiamine) is inactivated in the presence of mercuric chloride, acetates, carbonates, iodides, tannic acid, riboflavin, iron ammonium citrate, penicillin (penicillin), and glucose metabisulfite. thiamine activity is reduced in the presence of copper (catalysis gain) and an increase in pH.
Pyridoxine at a therapeutic dosage can reduce the effect of levodopa (antiparkinsonian effect) by increasing peripheral decarboxylation, so vitamin B6 does not apply with levodopa and drugs containing levodopa. Cyanocobalamin is inactivated in the presence of heavy metal salts.
If overdose occurs milgamma increased symptoms, relevant side effects. In case of overdose should syndromal and symptomatic therapy.
Milgamma - product form:
Milgamma available in parenteral form (intramuscular solution in 2 ml ampoule) and as tablets.
Milgamma - storage conditions:
In a darkened dry place away from children at a temperature of about 15 ° C.
Milgamma - Composition:
Milgamma - a solution for parenteral administration:
Active ingredients: thiamine hydrochloride, 100 mg of 2 ml vial, 100 mg of pyridoxine hydrochloride in 2 ml ampoule, cyanocobalamin - 1000 micrograms per 2 ml ampoule.
Auxiliary components: benzyl alcohol, lidocaine hydrochloride, sodium hydroxide, sodium polyphosphate, potassium hexacyanoferrate tertiary water for injection.