10 ampoules
For treatment of muscular dystrophy, coronary deficiency
International name:
Trifosadenin (Triphosadenine)
Group Affiliation:
Metabolic agent
Description of the active substance (INN):
Trifosadenin
Dosage form:
lyophilized for solution for intravenous solution for intravenous administration
Pharmacological Effects:
Metabolic means, has hypotensive and antiarrhythmic action, dilates coronary and cerebral arteries. Makroergicheskim is a natural compound. Formed in the body as a result of oxidation reactions and in the glycolytic cleavage of carbohydrates. Found in many organs and tissues, but most of all - in skeletal muscle. Improves metabolism and energy supply of tissues. Is split into ADP and inorganic phosphate, ATP releases large amount of energy used for muscle contraction, protein synthesis, urea, intermediate products of metabolism, etc. In the future decay products are included in the resynthesis of ATP. Under the influence of ATP, a reduction in blood pressure and relaxation of smooth muscles, improve conduct nerve impulses in autonomic ganglia and the transfer of excitation from n.vagus on the heart, increasing myocardial contractility. ATP suppresses automaticity sine-atrial node and Purkinje fibers (blocking Ca2 +-channels and increase permeability to K +).
Indications:
Supraventricular paroxysmal tachycardia (paroxysms). Previously, the drug used for the following reasons (currently due to low efficiency readings listed below are excluded): muscular dystrophy and atrophy, polio, multiple sclerosis, coronary insufficiency, post-infarction kardiomiodistrofiya, acute and chronic cardiovascular failure, obliterative arterial disease - Intermittent "claudication, Raynaud's disease, thromboangiitis obliterans (Buerger's disease), hereditary pigmentary retinal degeneration, the weakness of labor.
Contraindications:
Hypersensitivity, acute myocardial infarction, hypotension, inflammatory lung disease.
Side effects:
Allergic reaction (itching, redness of skin). When i / m administration - headache, tachycardia, increased diuresis, hyperuricemia, with I / O - nausea, hyperemia of the face, headache, weakness.
Dosage and administration:
V / m / in or / and. In the first days of treatment - a / m, and 10 mg (1 ml of 1% solution) 1 times a day, then at the same dose 2 times per day or 20 mg 1 time per day. Treatment course - 30-40 injections, a second course - in 1-2 months. For relief of supraventricular arrhythmias - IV, 10-20 mg for 5-6 s (effect occurs within 30-40 s), if necessary, possible re-introduction of 2-3 min.
Special instructions:
Should not be given in large doses in conjunction with cardiac glycosides.
Interaction:
Cardiac glycosides increase the risk of side effects (including arrhythmogenic action).
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