Captopril tablets 25mg #20

This medicine is an ACE inhibitor used to treat high blood pressure. It may also be used to treat congestive heart disease or to reduce the risk of heart failure and improve survival in some patients after a heart attack. 

Pharmacological action:
Is an inhibitor of the enzyme angiotenzinkonvertiruyushego, prevents the conversion of the physiologically inactive angiotensin I to angiotensin II - a major component of reninangibtenzinovoy system with pronounced vasoconstrictor (narrows the lumen of blood vessels) effect. The hypotensive (blood pressure lowering) effect of the drug due to lower blood levels of angiotensin II, aldosterone and decreasing formation (presumably) accumulation (accumulation) vasodepressor (expanding vascular lumen) bradykinin, in particular at low or normal levels of plasma renin. It reduces peripheral vascular resistance (resistance to the flow of blood vessels), decreases afterload (aortic blood pressure by decreasing peripheral vascular resistance) reduces right atrial pressure and small (pulmonary) circulation. Reduces the formation of aldosterone in the adrenal glands.

Indications for use:
Essential hypertension (persistent elevation of blood pressure of unknown cause); renal hypertension (persistent elevation of blood pressure due to kidney disease), especially renovascular (caused by disturbance of blood supply to the kidney), as a tool of choice in the treatment of refractory (resistant) to other drugs in hypertension.

How to use:
Doses set individually for each patient and can vary from 25 to 150 mg per day (3 hours). When hypertensive crises (quick and sharp rise in blood pressure) can be used sublingually (under the tongue) 25 mg. Renovascular hypertension when administered 12.5 mg.
3 times per day. In chronic heart failure appoint 12.5-25 mg 3 times a day. The maximum daily dose of 150 mg. For children the dose is set based 1-2 mg per 1 kg of body weight per day. The drug is taken on an empty stomach.

Side effects:
Maculopapular rash on the skin (skin rash), changes in taste, proteinuria (increased excretion of protein in the urine), increased levels of plasma creatinine, leukopenia (reduction in white blood cell count) and agranulocytosis (a sharp decrease in the level of granulocytes in the blood).

Contraindications:
Hypersensitivity to the drug, the tendency to edema, stenosis (narrowing) of the renal arteries, condition after kidney transplantation, aorta constriction, narrowing of the mitral valve, cardiomyopathy (heart disease of unknown origin is not controversial or inflammatory nature), primary hyperaldosteronism (increased secretion of the hormone aldosterone due to hyperplasia or tumors of the adrenal cortex, accompanied by edema, accumulation of fluid in the abdomen, high blood pressure), pregnancy, breast-feeding. Children up to 14 years, the drug is not prescribed. Patients whose activities are related to the need to fast focus and quick response (drivers of vehicles, operators, etc.), use caution during treatment. Should abstain from alcohol during treatment prparatom.

Product:
Tablets of 25, 50 and 100 mg in a package of items 20-30.

Storage conditions:
List B. In the dark spot.

Synonyms:
Hood, Tenziomin, Atsepril, acetyl, Alopresin, Capri, Katopil, Kaptolan, Lopirin, Proper, Tenzoprel, Apo Capte, Rilkapton, alkadienes, Angiopril, Sistopril.

40 tablets 25 mg

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