Exforge tablets 5mg/160mg #14

Exforge pharmachologic effect:
Exforge - antihypertensive drug containing a combination of two active substances. The first component - amlodipine, which belongs to the dihydropyridine derivative. Amlodipine - representative of blockers of slow calcium channels. Due to the impact on receptors to inhibit the movement of calcium into the cells into cardiomyocytes and endothelial cells of the smooth musculature. Due to this there is a relaxation of vascular walls, their expansion, reduction of peripheral vascular resistance. The drug reduces the resistance of the renal vascular endothelium, promotes the effective renal blood flow. Amlodipine is a natural reduction in blood pressure. The drug did not significantly affect the heart rate, the level of catecholamines. At therapeutic doses, in combination with beta-blockers is not observed negative inotropic action is detected impact on the functioning of the sinoatrial node, alters AV-conduction.

The second component - Valsartan, which is a receptor antagonist apparatus angiotensin II, AT1 selectively acting on receptors. The active ingredients in the combinations and dosages are complementary to each other effects. Use of the drug Exforge more effective than the use of amlodipine and valsartan as monotherapy. Under the influence of the blockade of the AT1 receptor, an increase in the concentration of plasma angiotensin II. Reduction in blood pressure observed after 120 minutes after a single use. Maximal hypotension develops an average of 5 hours. The duration of the hypotensive effect - more than a day. After discontinuation of the cancellation syndrome is not observed. Stable decrease in blood pressure was observed after 3 weeks of treatment and is maintained with long-term therapy. Use in patients with certain functional stages of heart failure, in the post-infarction period, reduces the number of hospitalizations and reduces mortality.

Exforge indications for use:
Exforge drug for hypertensive patients with indications for combination therapy.

Exforge mode of application:
The drug is indicated for internal use. The tablet is depending on the dose is received 1 time / day. Food does not affect the uptake and metabolism of the drug. In the presence of cholestasis, the dose correction is not carried out. The dosage is selected depending on blood pressure, tolerability.

Exforge side effects:
Receiving Exforge drug may be accompanied by: Nasopharyngitis; Constipation; Flu-like states; Cough; Exanthema; Headache; Paresthesias; Dizziness; Erythema; Epigastric pain; Pain in the throat; Hyperhidrosis; Muscle spasms; Visually impaired; Sleepiness; Nausea; Tachycardia; Itching; Pasty face; Hyperglycemia; Mucosal hyperplasia of the gums; Arthralgia; Erythema multiforme; Dry mouth; Tinnitus; Gastritis; Pain in the larynx; Orthostatic dizziness; Anxiety; Polyuria; Angioedema; Skin rash; Orthostatic hypotension; Syncope; Pancreatitis; Diarrhea; Tides; Swelling of the joints; Vasculitis; Erectile dysfunction; Hepatitis; Feeling of heaviness; Gynecomastia; Back pain; Rhinitis; Urticaria; Thrombocytopenia; Alopecia; Peripheral edema; Shortness of breath; Leukopenia; Asthenic conditions; Pollakiuria; Intensification of angina pectoris; Pulmonary edema; Lability of mood; Rhythm disorders; Insomnia; Sinusitis; An increase in serum creatinine level; Neutropenia; Peripheral neuropathy; Anaphylaxis.

Exforge contraindications:
The drug Exforge is not indicated when:

• Hypersensitivity to amlodipine, valsartan, auxiliary components;
• Pregnancy;
• Lactation;
• Renal artery stenosis;
• Recently undergone kidney transplantation;
• Indications in adolescents and children.

With caution is prescribed for Exforge:

• Hepatic dysfunction;
• Hypertrophic obstructive cardiomyopathy;
• Obstruction of the biliary tract;
• When kidney disease with creatinine clearance <10 mL / min;
• Hyperkalemia;
• Aortic stenosis;
• Mitral stenosis;
• Hyponatremia;
• Reduced BCC.

Exforge during pregnancy:
Exforge is contraindicated in pregnant women. The drug is not prescribed, if a woman is planning a pregnancy. Possible risk to the fetus due to the influence of the renin-angiotensin system. In establishing pregnancy drug overturned.

Exforge interaction with other drugs:
The drug, the pharmacological group of drugs results or physico-chemical interaction with the drug Exforge
Beta-adrenoceptor blockers Potentiation of antihypertensive and anti-anginal effects. Remedy associated with taking amlodipine reflex tachycardia. It is necessary to control blood pressure
Organic nitrates Summation antianginal action. Strengthening reflex tachycardia, the risk of hypotension
Inhibitors of CYP3A4 Increased plasma concentrations (PC) amlodipine
Inducers of CYP3A4 isoenzyme (phenytoin, carbamazepine, primidone, drugs St. John's wort, rifampicin, phenobarbital, fosphenytoin) Reduction of amlodipine PC
The risk of hyperkalemia potassium-containing drugs
Potassium-sparing diuretics, risk of hyperkalemia
The weakening of the hypotensive effect of NSAIDs
Diuretics The risk of deterioration of renal function, the risk of hypoglycaemia
Antidiabetic drugs hypoglycemia Gain
Blockers alpha-adrenoceptor Increased hypotensive effect
Lithium Drugs Decrease lithium excretion by the kidneys, increase the toxicity of lithium-containing medicines
Funds for general anesthesia Significant hypotension

Exforge overdose:
Official reports of drug Exforge overdose has been reported. It is theoretically possible development of hypotension, dizziness, reflex tachycardia, shock. If swallowed a large number of tablets should cause vomiting, stomach hold cleaning, take drugs, sorbents. The position of the patient with an overdose and the development of hypotension - lying with raised legs. Perhaps the appointment of vasoconstrictor drug, the use of calcium gluconate. Hemodialysis is ineffective.

Exforge product form:
Exforge drug is marketed in tablet form. Filling Machine are as follows:
- Table. 5/80 mg 14 pcs .;
- Table. 5/80 mg 28 pcs .;
- Table. 5/160 mg 14 pcs .;
- Table. 5/160 mg 28 pcs .;
- Table. 10/160 mg 14 pcs .;
- Table. 10/160 mg 28 pcs.

Exforge storage conditions:
Storage temperature pill Exforge - up to 30 degrees Celsius. The product is fit for 3 years from the production date.

Exforge synonyms:
Difors.

Exforge composition:
1 tablet contains Exforge 5/80 mg amlodipine besylate 6.94 mg, 80 mg valsartan. Auxiliary components: MCC, crospovidone, magnesium stearate, PEG 4000, silica, talc, titanium dioxide, iron oxide yellow, water, hypromellose.
1 pill Exforge 5/160 mg contains amlodipine besylate 6.94 mg, valsartan 160 mg. Auxiliary components: MCC, crospovidone, magnesium stearate, PEG 4000, silica, talc, titanium dioxide, iron oxide yellow, water, hypromellose.
1 pill Exforge 10/160 mg amlodipine besylate contains 13.87 mg, 160 mg of valsartan. Auxiliary components: MCC, crospovidone, magnesium stearate, PEG 4000, silica, talc, titanium dioxide, red iron oxide, water, hypromellose.

Exforge pharmacological group:
Cardiovascular drugs: Antagonists of calcium ions

Exforge active ingredients:
Amlodipine, Valsartan

Additionally:

When CC 30-50 ml / min dosage of the drug Exforge correction is required.
The drug is not Eksfrzh relieves withdrawal symptoms when you stop receiving beta-blockers. Because of this, the abolition of the beta-blockers spend mild.
Before therapy requires correction fluid and sodium in the body. Initiation of therapy is carried out under the supervision of a physician.

With the development of arterial hypotension, the patient is placed in a prone position, legs lifted, carried infusion nat. solution to aid in the stabilization of blood pressure. After stabilization, therapy may be continued.
Driving of vehicles, hazardous activities while using the drug can become a life-threatening occupation because of side effects in the form of dizziness, asthenia.

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