Phencarol 25mg #20

Pharmacological properties

hifenadin (hinuklidil-3-difenilkarbinola hydrochloride) - a derivative hinuklidilkarbinola, a competitive blocker of H1-receptors. Furthermore, in contrast to the classical antihistamines, it activates the enzyme diaminoksidazu, which breaks down to 30% of tissue histamine. This explains the effectiveness of fenkarol in patients in whom the use of other antihistamines is ineffective. Fenkarol poorly crosses the BBB and has little effect on the processes of deamination of serotonin in the brain, has little effect on MAO activity. Antihistamines hifenadina properties associated with the presence of cyclic quinuclidine core in the structure and distance between the group and the nitrogen atom difenilkarbinola. By protivogistaminnoy activity and duration of action exceeds fenkarol diphenhydramine. Reduces the biological effects of histamine, in particular, eliminates or reduces its bronchoconstrictor effect spazmiruyuschee effect on smooth muscle of the intestine, the hypotensive effect and influence on capillary permeability, has a moderate and weak protivoserotoninovym anticholinergic effect, pronounced antipruritic and desensitizing properties. Fenkarol has no direct effect on cardiac function and blood pressure. In contrast, diphenhydramine, and diprazina hifenadin has no inhibitory effect on the CNS. The drug is lipophilic and small, in comparison with antihistamines, depressing the central nervous system, its concentration in brain tissue is low (less than 0.05%), which explains the lack of inhibitory effects on the CNS.

 

Pharmacokinetics

Rapidly absorbed from the digestive tract, after 30 min the drug found in the tissues of the body. The maximum concentration in serum is reached after 1 h and constant hifenadin metabolites mainly excreted in the urine and bile within 48 hours

 

Indications for use

pollinosis and food and drug allergy, other allergic diseases, acute and chronic urticaria, angioedema, hay fever, allergic rinopatiya, dermatitis (eczema, psoriasis, atopic dermatitis, pruritus) and upper respiratory tract infection with bronhospasticheskim component.

 

Dosage and administration

inside immediately after a meal, adults - 25-50 mg 3-4 times a day. In hay fever the daily dose less than 75 mg is not effective. The maximum daily dose is 200 mg. Duration of treatment - 10-20 days. Children under the age of 3 to 5 mg administered 2-3 times daily, 3-7 years - 10 mg two times daily, 7-12 years - 10-15 mg 2-3 times per day, over 12 years - 25 mg 2-3 times a day. The recommended daily dose can be administered in four doses. The duration of treatment is 10-15 days. If you receive another dose is omitted, it is necessary to continue treatment at previous dose.

 

Side effects

hypersensitivity or overdose can be observed moderate dryness of the oral mucosa, dyspeptic symptoms, which usually resolves with dose reduction or cancellation of a preparation. The risk of side effects is increased in patients with diseases of the digestive tract.

 

Contraindications

I trimester of pregnancy, hypersensitivity to the drug.

Interaction with other medicinal products

does not enhance the inhibitory effect of alcohol and sleeping on the CNS. Fenkarol has a weak M-anticholinergic properties, so by reducing the motility of the gastrointestinal tract can increase absorption of medlennoabsorbiruyuschihsya medicines (eg, indirect anticoagulants coumarin).

 

Overdose

at a dose of 300 mg / day does not cause severe side effects. In high doses, may cause dryness of mucous membranes, headache, epigastric pain, vomiting and other dyspeptic symptoms.

 

Features of the application

Use caution in severe diseases of the cardiovascular system, gastrointestinal tract or liver. No evidence of penetration of the drug in breast milk, so his appointment during lactation should be careful. Persons whose work requires physical or mental quickness of the reaction (the drivers of vehicles, etc.) should be pre-set (by short-term use), whether the drug has no sedative effect.

 

Terms and Conditions of storage

in a dry, dark place.