Cycloferon solution 12,5% amp 2ml #5

Cycloferon solution 12,5% amp 2ml #5
Manufacturer: Russia
Product Code: 921
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Cycloferon solution 12,5% amp 2ml #5

Cycloferon is an antiviral used to treat shingles, chickenpox, genital herpes, herpes infections of the skin, and oral herpes (i.e., cold sores). 

5 ampoules 2ml

Pharmacological action:
Cycloferon refers to the immunomodulating and antiviral agents. The drug is a high inductor formation of endogenous interferon. Efficacy caused broad spectrum of biological activity: anti-inflammatory, antiproliferative, antiviral, immunomodulatory, antitumor activity. Cycloferon when administered to potentiate the formation and maintenance in the tissues and organs of high titers of beta- and alpha-interferon.

Particularly high levels of interferon is defined in the tissues and organs that contain a large number of lymphoid elements: the liver, spleen, lungs, intestinal mucosa. Just drug activates the bone marrow stem cells, causing the rapid formation of granulocytes. Normalizes the ratio of T-helper and T-suppressor, promotes activation of NK cells and T lymphocytes. When immunodeficiencies of various origins it is a correction of the immune status of the organism. Is able to penetrate the blood-brain barrier.

Cycloferon causes clinical improvement in viral infections (herpes, influenza, encephalitis, hepatitis, cytomegalovirus infection, HIV infection, papillomatous and enterovirus infection). Due to activation of the immune system has protivohlamidiynoe and antimicrobial action. Prevents the formation of neoplastic processes in the body due to the anti-metastatic and protivokantserogennogo action. Suppresses autoimmune reactions, manifested a significant reduction in pain and inflammation in systemic connective tissue diseases and rheumatic diseases.
When applied topically to improve the balance Cycloferon causes the immune system as well has antiproliferative and anti-inflammatory action.

After receiving the inner Cyclopheron a maximum dosage of active substance found in maximum plasma concentration of 2-3 hours. In the future, the drug concentration is reduced to 8 o'clock. Day after receiving Cycloferon can detect in the body in trace concentrations. The half-life is 4-5 hours. In appointing Cyclopheron the recommended dosages of the active substance accumulation was observed.

Indications for use:
Cycloferon - Tablets
For adults - in the complex therapy:

  • herpes infection,
  • influenza and ARI (acute respiratory infections)
  • acute intestinal infections,
  • neuroinfections (including tick borellioz - Lyme disease, serous meningitis)
  • secondary immunodeficiency caused by chronic fungal and bacterial infections.
  • viral chronic hepatitis C and B,
  • HIV infection in clinical stage 2A-3B.


In Pediatrics - as part of combination therapy with:

  • herpes infection,
  • chronic and acute viral hepatitis C and B,
  • HIV infection in clinical stage 2A-3B,
  • acute intestinal infections,
  • for the treatment and prevention of acute respiratory diseases and influenza.


Cycloferon for parenteral use
For adults - in the complex therapy:

  • HIV infection in clinical stage 2A-3B,
  • viral hepatitis C, A, D and B,
  • systemic connective tissue diseases and rheumatic diseases (systemic lupus erythematosus, rheumatoid arthritis)
  • neuroinfections (including tick borellioz - Lyme disease, serous meningitis, encephalitis)
  • cytomegalovirus or herpes infection,
  • secondary immunodeficiency, caused by chronic or acute fungal and bacterial infections,
  • Chlamydia infection,
  • degenerative joint disease (including osteoarthritis deformans).

In Pediatrics (children older than 4 years) - in the complex therapy:

  • viral hepatitis C, A, D, GP and B,
  • herpes infection,
  • HIV infection in clinical stage 2A-3B.

Cycloferon topical
As an integral component of complex treatment in adults with:

  • herpes infection,
  • nonspecific therapy and bacterial vaginosis vagititov,
  • balanoposthitis treatment, specific urethritis (chlamydia, gonorrhea, trichomonas), Candida and nonspecific etiology.

How to use:
Cycloferon - Tablets
Assign 1 times a day for half an hour before a meal. Tablet wash down with water, do not chew.

When herpes infection for adults Cycloferon appoint an appointment 2-4 tablets under the scheme: 1 st, 2, 4, 6, 8, 11, 14, 17, 20 and 23 th days (basic scheme) - Throughout the course of therapy - 20-40 tablets (3.6 g). Treatment starts at the time of exacerbation.

Acute respiratory infections and flu - 2-4 tablets 1 time per day. Throughout the course of treatment - 10-20 tablets (1.5-3 g). Prescribed for the first symptoms of the disease. In case of severe clinical picture can be used for the first reception of 6 tablets. Treatment Cycloferon combined with analgesic, antipyretic and expectorants (if necessary and if indicated).

In chronic viral hepatitis C and B - on the reception circuit 4 pills of 1 st, 2, 4, 6, 8, 11, 14, 17, 20 and 23 th days. Next, move on to support the drug 4 tablets 1 every 3-5 days for 3.5 months (save in the case of cytolytic activity and replicative infection). Throughout the course of treatment - 100-150 tablets. The course of treatment must be repeated if the patient has hepatitis C or mixed-form infection. Repeated courses Cyclopheron appoint 2 times: each - 1 month after the end of the previous one. Administered in combination with antiviral drugs and interferon.

Intestinal infections (in the complex treatment) assigned to receive 2 tablets under the scheme: 1 st, 2, 4, 6, 8 days. Next - to accept 2 tablets 11 minutes, 14, 17, 20 and 23 th days. Throughout the course of treatment - 20 tablets (3 g).

When neuroinfections administered 4 tablets per reception scheme: 1st, 2, 4, 6, 8, 11, 14, 17, 20 and 23 th days. Then move on to maintenance dosage - to receive 4 tablets 1 time in 5 days. Total treatment duration of 2.5 months (100 ml - 15 g).

HIV infection in clinical stage 2A-3B are assigned to the reception circuit 4 pills of 1 st, 2, 4, 6, 8, 11, 14, 17, 20, 23 th day of treatment. Next, move on to maintenance dose: at the reception 4 tablets 1 time in 3-5 days. Duration of treatment - 2,5 months. Throughout the course of 100-150 tablets. After the end of the previous course in 2-3 weeks treatment is repeated in the same way.

When administered to the reception immunodeficiencies tablets Scheme 2: 1st, 2, 4, 6, 8, 11, 14, 17, 20, 23 th day of treatment. Throughout the course of treatment - 20 tablets (3 g).
In Pediatrics Cycloferon designate in the following doses: for children 4-6 years - taking 1 pill (150 mg), aged 67-11 years - by taking 2 tablets (300 mg), 12 years - to receive 3 tablets (450 mg), 1 time per day. If necessary, repeat the course of therapy Cycloferon administered 2-3 weeks after the end of the previous course.

Viral acute hepatitis C and B: Use the recommended dosage for children 2 times with an interval of 24 hours. Then designate 3 times every 48 hours. In the future, use 5 receptions Cyclopheron 72 hours. Depending on the age of only therapy - 10-30 tablets.

Viral chronic hepatitis C and (or) In: Cycloferon prescribed in the recommended dosages for children with an interval of 48 hours. Throughout the course of treatment - 50-150 tablets (depending on age).

HIV infection in clinical stage 2A-3B Cycloferon administered to children at the recommended dosage scheme: 1st, 2, 4, 6, 8, 11, 14, 17, 20-th day of treatment. Then move on to support receiving one every 3-5 days for 5 months.

When herpes infection is prescribed under the scheme: 1 st, 2, 4, 6, 8, 11, the 14th day of treatment. The duration of the drug depends on the severity of clinical manifestations and severity of disease.

Intestinal acute infections prescribed by the scheme: 1 st, 2, 4, 6, 8, 11 th days of treatment 1 time per day are recommended for pediatric doses. Throughout the course of treatment 6-18 tablets.

During the period of the epidemiological situation unfavorable for the prevention of influenza and acute respiratory diseases Cycloferon administered in doses recommended for children under the scheme: 1 st, 2, 4, 6, 8 days, then - still 5 times with an interval of 72 hours. A course of treatment - 10-30 tablets.
With the flu and acute respiratory diseases Cycloferon administered in recommended doses for children with an interval of 24 hours. A course of treatment - 5-9 treatment (1 per day).

Cycloferon for parenteral use
Use basic scheme of administration (days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23, 26, 29-th day of treatment), that will depend on the type of disease. Used intravenously or intramuscularly 1 time per day.

In viral hepatitis B, A, D, C single dose of 250-500 mg is Cyclopheron. Throughout the course of treatment - 10 injections to the standard regimen. The total cumulative dose of 2.5-5 course is repeated after 10-14 days.

Cytomegalovirus and herpes infections Cycloferon appoint basic scheme. Throughout the course of treatment - 10 injections of 250 mg. The total cumulative dose of 2.5 g The most effective use of the drug at the beginning of exacerbation.

When neuroinfections Cycloferon appoint basic scheme. Throughout the course of treatment - 12 injections of 250-500 mg. Drug treatment should be combined with a causal therapy. The total cumulative dose of 3-6 if necessary treatment can be repeated.

HIV infection in clinical stage 2A-3B Cycloferon administered in a single dose of 500 mg intramuscularly. Throughout the course of treatment by the standard regimen - 10 injections. The total accumulated dose of 5 g After the basic course prescribed maintenance treatment 1 in every 5 days for 2.5 months. 1 month after the end of the last course appoint a second course of therapy.

When chlamydial infection Cycloferon prescribe a dose of 250 mg. Throughout the course of treatment - 10 injections. The total cumulative dose - 2.5 g After 10-14 days after the last course appoint a second course of therapy.
Recommended Cyclopheron combination with antibacterial drugs.

When immunodeficiency appoint 10 injections per treatment. Used intramuscular injection of the drug at a dose of 250 mg of the standard regimen. The total cumulative dose of 2.5 g 6-12 months after the last course appoint a second course of therapy.

In systemic connective tissue diseases and rheumatic diseases prescribed regimen of basic Cyclopheron 5 injections (4 courses). Dose - 250 mg with an interval of 10-14 days. The need for re-appointment Cyclopheron determined by the physician individually.

When degenerative diseases of the musculoskeletal system is assigned to the standard regimen of 250 mg - 2 courses for all 5 injections with an interval of 10-14 days. The need for re-appointment Cyclopheron determined by the physician individually.
In pediatrics: daily dose Cyclopheron calculated from 6-10 mg / kg body weight of the patient. Applied intramuscularly or intravenously 1 times a day.

In acute viral hepatitis B, A, G, GP, D-forms and mixed Cycloferon administered according to the scheme 1-st, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, the 28-day treatment. In the event of a prolonged course of infection must repeat the course in 10-14 days.

In chronic viral hepatitis C and B, GP, D Cycloferon administered according to the scheme 1-st, 2, 4, 6, 8, 10, 12, 14, 16, 18-th day of treatment. Then - 1 maintenance therapy every 3 days for 3 months (in the case of conservation of cytolytic activity and replicative infection).

HIV infection Cycloferon administered according to the scheme 1-st, 2, 4, 6, 8, 10, 12, 14, 16, 18-th day of treatment. Maintenance therapy is then used 1 time in 5 days to 3 months (in the case of conservation replicative activity of the infectious process). When the mixed forms of infections (HIV, hepatitis), chronic hepatitis C may be extended maintenance treatment for up to 6 months.

When herpes infection Tsitkloferon administered according to the scheme 1-st, 2, 4, 6, 8, 11, 14, 17, 20, 23 th day of treatment. Therapy may be continued up to 4 weeks maintenance dosage - single administration every 5 days.

Cycloferon topical
When herpes infection: cycloferon liniment is applied to the affected area with a thin layer of 1 times a day for 5 days. In the case of genital herpes conduct daily intraurethral and (or) intravaginal instillation of 1 bottle of liniment (5 ml) 1 times a day for 10-15 days. Liniment can be combined with other local and systemic antiherpethetical means.

When Candida and nonspecific urethritis carried instillation into the urethra in an amount of 1-2 vials (5.10 ml). The dose is dependent upon the level of urethral lesions. In the case of a pathological process in the anterior part of the male urethra cannula syringe recruited cycloferon liniment immersed in the external opening of the urethra, and then the hole is compressed by 1.5-3 minutes. After some time instillyatsionny solution stands out by gravity. Half an hour later the patient should urinate because longer exposure Cyclopheron can cause swelling of the mucous membrane of the urethra. In case of defeat back of the urethra and (or) testes using intraurethral instillation of the drug through the urethral catheter in an amount of 1-2 vials (5-10 ml) cycloferon liniment for 10-14 days 1 times a day every other day. Throughout the course of treatment - 5-7 instillations.
For the treatment of specific urethritis necessary addition in the form of specific antibacterial agents used on standard schemes.

When Candida coleitis, bacterial vaginosis, nonspecific coleitis and (or) endocervicitis Cyclopheron can use as monotherapy or as part of a comprehensive treatment. Applied instillation Cyclopheron-liniment vagina vials in an amount of 1-2 (5-10 ml) for 10-15 days every day. To avoid leakage of liniment free entrance to the vagina must zatamponirovat sterile cotton swab small size for 2-3 hours. When combined intravaginal infection and intraurethral instillation is recommended to combine the use of the vagina and the urethra in an amount of 1 vial (5 ml) for 10-15 days every day. May be used as a liniment drug-soaked tampons.

Liniment Cycloferona can be combined with other officinal vaginal dosage forms in the case of chronic diseases (vaginal suppositories, tablets).

Side effects:
Allergic reactions to Cycloferon and other components of the drug.

Contraindications:

  • to receive the inner and parenteral administration - cirrhosis (decompensated)
  • allergic reactions Cycloferon agents and other components.

Pregnancy:
Cycloferon contraindicated for pregnant women and nursing mothers. During lactation can not counter liniment Cycloferona.

Interaction with other drugs:
The drug is fully compatible with other drugs that are prescribed for treatment of these diseases (including chemotherapy and interferon).

Overdose:
No information available.

Product:

  • Tablets Cycloferon - enteric coated brown or golden brown. The tablets are available in jars or plastic dark glasses (50 pieces) and in blister packs of 10 pieces. In a cardboard box 1 or 5 blisters.
  • Cycloferon - injection - in 2 ml ampoules (12.5%). In ampoule - yellow liquid, transparent. 1 ml injection solution contains 125 mg (1 vial - 250 mg). In a cardboard box of 5 ampoules in a contour packaging.
  • Liniment Cycloferona 5% - yellow liquid ointment 5 ml tube.

Storage conditions:
Cycloferon should be stored in protected from light, dry place at a temperature of 18-20 ° C. And liniment tablets stored no longer than 2 years; injection - 3 years. May momentarily freezing solution for injection (during transportation) - it does not alter the drug and the physicochemical properties of the drug. The frozen solution is thawed for injection necessary only at room temperature. In the case of precipitation or when changing the color of the solution for injection drug can not be used.

Ingredients:
tablets Cycloferon
Active ingredients: akridonuksusnaya acid (150 mg tablet), N-methylglucamine (146 mg per tablet).
Inactive ingredients: calcium stearate, methylcellulose.

Solution for injection Cycloferon
Active ingredients: akridonuksusnaya acid (125 mg in 1 ml 250 mg in 1 vial).
Inactive ingredients: water for injection, salt-forming and stabilizing additive (N-methyl glucamine 192.9 mg in 2 ml).

liniment Cyclopheron
Active ingredients: akridonuksusnaya acid salt form N-methylglucamine (50 mg in 1 g liniment).
Inactive ingredients: 1,2-propylene glycol to 100% (base), 0.1% catapol (antiseptic).

In addition:
Use of the drug by mouth or by injection in diseases of the thyroid gland should be carried out under the close supervision of a physician, an endocrinologist.

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