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Coldrex MaxGrip is one of the few non-prescription drugs in Russia containing paracetamol at the maximum single dose - 1000 mg. Coldrex MaksGripp for those who require urgent and most effective elimination of acute symptoms of the disease. Coldrex MaksGripp quickly lowers the temperature, relieves fever, muscle pain, joint pain and headache, relieves nasal congestion, sinus pain, eliminates the nose and throat. Please note that it is not recommended to take more than 4 hours and not more than 4 bags per day.
Paracetamol - medicated group of non-steroidal anti-inflammatory drugs, and has a strong analgesic and antipyretic, anti-inflammatory effect of the drug is negligible. Paracetamol inhibits the cyclooxygenase enzyme, whereby there is slow metabolism of arachidonic acid and decreased synthesis of prostaglandins, prostacyclin and thromboxane. The analgesic effect of the drug is carried out by reducing the amount of prostaglandins in the tissues of the central nervous system. Paracetamol directly affects the thermoregulatory center in the hypothalamus, which leads to reduction of elevated body temperature.
Phenylephrine hydrochloride - sympathomimetic drug, helps constrict blood vessels located in the mucous membrane of the nose and paranasal sinuses. Phenylephrine eliminates swelling of the mucous membranes of the nose, reducing rhinorrhea, nasal breathing easier.
Ascorbic acid (vitamin C) - has a strong antioxidant and an immunostimulating action. Ascorbic acid enhances the phagocytic activity of macrophages, enhances the non-specific immune response. In addition, vitamin C protects cells and tissues from the negative effects of free radicals and peroxides.
After all oral drug components are well absorbed from the gastrointestinal tract. Peak concentrations of paracetamol in plasma observed after 30-120 minutes after oral administration of phenylephrine - after 1-2 hours. Paracetamol and ascorbic acid is metabolized in the liver, phenylephrine hydrochloride is metabolized in the gut and liver.
The active ingredients of the drug in the urine excreted mainly as unchanged as well as metabolites. Some part of ascorbic acid is excreted in the bile. The half-life is 1-4 hours of paracetamol, phenylephrine - 2-3 hours.
Indications for use:
The drug is used for the symptomatic treatment of acute respiratory infections and influenza, which are accompanied by fever, swelling of the mucous membranes of the nose, rhinorrhea, headache and myalgia.
How to use:
The drug is used for preparation of a solution for oral administration. The contents of the bag must be completely dissolved in a glass of hot drinking water. The drug is taken with or without food. The duration of treatment and the dose determined by the attending physician for each patient individually.
Adults and adolescents over the age of 12 years, usually on 1 bag of the drug 1-4 times a day. Care must be an interval of at least 4 hours between doses of the drug.
The maximum daily dose is 5 bags.
The duration of treatment should not exceed 5 days, if the doctor otherwise directed.
If within 3 days of therapy with fever is not reduced, or there is a second increase in body temperature, you should contact your doctor.
If necessary, use more than 7 consecutive days should monitor liver function and blood count.
Side effects:
The drug is generally well tolerated in some instances, indicated the development of such side-effects:
On the part of the gastrointestinal tract and liver: nausea, vomiting, diarrhea, dry mouth, anorexia, elevation of liver enzymes.
Cardio-vascular system and blood: irregular heartbeat, hypertension, leukopenia, neutropenia, thrombocytopenia, anemia, agranulocytosis, pancytopenia.
On the part of the central and peripheral nervous system: headache, dizziness, sleep and wakefulness, irritability, tremor of limbs, ringing in the ears.
Urinary system: oliguria, renal colic, nephrotoxicity.
Allergic reactions: skin rash, pruritus, urticaria, angioedema, toxic epidermal necrolysis, anaphylaxis.
Other: increased sweating, changes in the level of glucose in the blood.
Contraindications:
Hypersensitivity to the drug.
A severe form of liver and / or kidney failure, hyperthyroidism, hypertension.
The drug is not used for the treatment of patients suffering from heart disease, diabetes, chronic alcoholism, a violation of hematopoiesis, acute pancreatitis, prostatic hypertrophy, and epilepsy.
The drug is contraindicated in patients receiving therapy with inhibitors of monoamine oxidase.
The drug should not be given to women during pregnancy and for children under the age of 12 years.
The drug should be used with caution in patients over the age of 65 years, as well as patients suffering from diseases of the liver and kidneys, Raynaud's disease, angina, and pheochromocytoma.
1 package of the drug contains 2.9 grams of sugar.
Pregnancy:
The drug is contraindicated in women during pregnancy.
The use of the drug during lactation is possible only after consultation with your doctor, who should decide on the possible cancellation of breastfeeding.
Interactions with other drugs:
Preparation is not used in conjunction with other drugs for the symptomatic treatment of acute respiratory disease, drugs containing acetaminophen and ethyl alcohol.
Simultaneous use of the drug is contraindicated with tricyclic antidepressants, beta-adrenergic blockers and inhibitors of monoamine oxidase. Use of the drug may not be earlier than 14 days after the last use of monoamine oxidase inhibitors.
With the simultaneous use of the drug with metoclopramide and domperidone marked increase in the rate of absorption of paracetamol when used in conjunction with cholestyramine - reducing the rate of absorption of paracetamol.
The combined use of the drug enhances the anticoagulant effect of warfarin.
With the simultaneous use of the drug with barbiturates, anticonvulsant drugs, isoniazid and rifampicin ethanol has increased, hepatotoxicity of paracetamol.
Phenylephrine hydrochloride reduces the effectiveness of antihypertensive drugs and beta-adrenergic blockers.
Overdose:
In the application of excessive doses of the drug, patients have the development of nausea, vomiting, headache, pallor, loss of appetite, pain in the epigastric region. With a further increase in the dose may develop hypertension and hepatic toxicity of the drug. Using the drug in doses much higher than recommended may develop encephalopathy, severe liver failure, metabolic acidosis and coma.
If overdose is shown gastric lavage, enterosorbents and symptomatic therapy. If overdose hospitalization is shown. Symptoms of severe paracetamol poisoning usually develop within 12-48 hours. In severe poisoning with paracetamol shown intravenous acetylcysteine and oral methionine.
Product:
Powder for solution for oral use in 5g sachets of 5 or 10 bags in a carton box.
Storage:
The drug should be stored in a dry place away from direct sunlight at temperatures between 15 and 25 degrees Celsius.
Shelf life - 3 years.
