Diazolinum dragee 50mg #20

Diazolinum dragee 50mg #20
Manufacturer: Ukraine
Product Code: 5
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Diazolinum dragee 50mg #20

Pharmacological properties
Pharmacodynamics refers to Mebgidrolin antihistamines, H1-blocker is a histamine receptor. Mebgidrolin weakens spasmogenic effect of histamine on bronchial smooth muscle, intestine, and its effect on vascular permeability. Unlike first-generation antihistamines (diphenhydramine, suprastin, etc.) has a less pronounced sedative and hypnotic effect. It has mild anticholinergic m and anesthetic properties.
Rapidly absorbed from the digestive tract. Bioavailability of 40-60%. The therapeutic effect develops after 15-30 min, the maximum effect is observed after 1-2 h duration of effect up to 2 days. The drug is virtually does not penetrate the blood-brain barrier and is metabolized in the liver by methylation, induces liver enzymes excreted by the kidneys.
Prevention and treatment of seasonal and allergic rhinitis, hay fever, hives, food and drug allergies, skin reactions after insect bites, skin diseases accompanied by itching (eczema, atopic dermatitis).
Diazolin ® is administered orally after a meal, adults and children 12 years old, 100 mg - 200 mg 1-2 times a day. Higher doses for adults: a single dose - 300 mg daily dose - 600 mg. Children 5-12 years 50 mg administered 2-3 times a day, 3-5 years 50 mg 1-3 times. Duration of treatment depends on the severity and course of illness.
Side effect
Part of the digestive system: diazolin ® may irritate the mucous membranes of the gastrointestinal tract, sometimes manifested dyspeptic symptoms (heartburn, nausea, epigastric pain, etc.).
CNS: dizziness, paresthesia, fatigue, drowsiness, blurred vision, slow reaction rates.
Other: dry mouth, impaired urination, and allergic reactions. Very rarely may cause granulocytopenia and agranulocytosis.
Hypersensitivity to the drug. Peptic ulcer and duodenal ulcer during the exacerbation, and other inflammatory diseases of the digestive tract, prostatic hypertrophy, pyloric stenosis.
With an overdose of the drug and increased risk of adverse reactions, as described in the relevant section. In this case, medication overturned, if necessary, implement measures general detoxification (gastric lavage, forced diuresis), symptomatic therapy.
Features of the application
 Diazolin ® prescribed with caution in severe hepatic and / or renal insufficiency (a correction dose and intervals between doses). The drug is not recommended for angle-closure glaucoma, epilepsy, heart rhythm disorders.
During treatment diazolin ® consumption of alcoholic beverages is not recommended.
Children are sometimes observed paradoxical reactions: increased arousal, irritability, tremors, sleep disturbances. Not recommended for use up to 3 years in the form of pills.
Application diazolin ® during pregnancy and lactation is possible only if the expected effect outweighs the risk of possible adverse reactions.
Effects on ability to drive trucks and work with others diazolin 0.05, the number 20nimy mechanisms. Using the drug is not recommended for driving and doing other potentially hazardous activities that require concentration.
Interactions with other drugs
Diazolin ® potentiates the effects of sleeping pills, sedatives and other drugs that depress the central nervous system, as well as alcohol.
Terms and Conditions of storage
 Store in a dry, dark place at temperatures above 25 ° C.
Shelf-life - 3.5 years.
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