Movalis is used to treat the symptoms of osteoarthritis, a painful joint disease most commonly affecting the hips, knees, and spine.
Pharmachologic effect:
The main active ingredient of the drug is meloxicam. This is a non-steroidal anti-inflammatory agent that is a selective inhibitor of cyclooxygenase-2. This enolievoy acid derivative. The active substance has on the analgesic, anti-inflammatory and antipyretic effect, and also blocks the specific enzyme that is directly involved in the development of inflammatory processes.
Pharmacokinetics:
Distribution: The active ingredient of the drug binds to the plasma protein at 99 percent. Penetration into the inflamed organs occurs through the blood-tissue barriers.
Metabolism: Metabolize in the liver.
Breeding: It occurs within 20 hours after administration. About 5 percent of the daily dose of the drug unchanged through the intestines.
Indications for use:
- Rheumatoid arthritis;
- Symptoms of osteoarthritis;
- Symptoms of ankylosing spondylitis (Bechterew's disease):
- Pain syndromes in osteoarthritis, arthritis, degenerative joint diseases.
Side effects:
In fact, the drug can affect almost all organs and body systems.
Digestive system:
Nausea, vomiting, abdominal pain, bloating, diarrhea, constipation can experience up to 5 percent taking the drug. Other symptoms (such as belching, esophagitis, ulcerative lesions of the gastrointestinal tract, hidden or macroscopic gastrointestinal bleeding, colitis and gastritis) experiencing less than 0.1 percent.
Hematopoietic system:
Occasionally use of the drug can cause anemia, more rarely - leukopenia, thrombocytopenia, promotes changes in the number of certain types of white blood cells in the unit.
Skin reactions:
Itching, rash, stomatitis, rash, photosensitivity.
In some cases it may appear allergic reactions.
Respiratory system:
Very rarely can be acute attacks of asthma.
Nervous system:
Headaches, dizziness, tinnitus, drowsiness, mood swings, nervousness.
The cardiovascular system:
Swelling, change in blood pressure, hot flushes and palpitations.
Vision:
Blurred vision and conjunctivitis.
Contraindications:
In this drug are enough of them. In appointing him, be sure to inform the doctor about the presence of you the following diseases and disorders in the work of:
- The active phase of peptic ulcer;
- Severe hepatic and renal failure;
- Hypersensitivity to any drugs and allergic reactions;
- Pronounced "Aspirin" triad (inherently a combination of recurrent nasal polyposis, and paranasal sinuses, asthma and intolerance to drugs pirazolonovogo series).
Contraindications for movalis injecting a patient receiving anticoagulants because it may trigger the development of intramuscular hematoma.
Rectal administration of the drug is extremely undesirable in inflammatory diseases of the rectum and anal department.
Contraindications to administration of the drug is also an elderly age, pregnancy and lactation.
Pregnancy:
The drug is contraindicated.
Interaction with other drugs:
If the treatment of any kind, that may be appointed by the administration of drugs of diseases from the group of NSAIDs, it is possible the risk of diseases of the gastrointestinal tract, bleeding and the development of ulcer disease. In some cases, the drug may reduce the effectiveness of intrauterine devices. Patients who used movalis with diuretics, must first examine their kidneys and constantly consumed liquid in sufficient quantity.
In addition, the drug significantly reduces the effect antigiperztivnyh means.
Can provoke retention of sodium, potassium, reduces the effect of saluretikov possibly the progression of heart failure, arterial gipertnezii.
The injection should not be mixed in the same syringe with others.
When concomitant administration anatatsidov, tsimetidana, digoxin, furosemide with meloxicam pharmacokinetic drug interactions have been identified.
Overdose:
In case of overdose may increase the above-mentioned side effects of the drug. To avoid this, it is recommended gastric lavage.
Product form:
Available in the form of tablets and capsules, suspensions for oral administration, injectable solutions and suppositories for rectal use.
Storage conditions:
Store in a cool, dark place. The maximum temperature at which the drug can be stored must not exceed 30 degrees.
Shelf-life 5 years.
Synonyms:
Meloxicam (Meloksicam)
Pharmacological group:
Painkillers and anti-inflammatory drugs
Nonsteroidal anti-inflammatory drugs
Additionally:
Particular caution is necessary to prove the appointment of the drug to elderly people.
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