Pharmacological action:
Pimafucin - antifungal agent. The active ingredient of the drug is natamycin - polyene macrolide antibiotic series. It has a wide spectrum of action. Exhibits fungicidal activity as sterols blocks of cell membranes of fungi, which leads to death of the microorganism. Sensitive to the fungi of the genus Candida spp. Several exhibits less sensitivity to dermatophytes. To date, the clinical practice no cases of resistance to natamycin.
Natamycin is practically not absorbed in the alimentary canal, is not absorbed from mucous membranes and skin. Due to the enteric coating tablets Pimafutsin effect observed in the intestines.
Indications:
Infections fungal etiology, caused by organisms susceptible to natamycin:
· Vulvovaginal candidiasis;
· Fungal diseases of the gastrointestinal tract caused by immune deficiency, cachexia, receiving cytostatics, antibiotics, corticosteroids (including acute pseudomembranous candidiasis and atrophic, intestinal candidiasis);
· Comprehensive treatment in the case of systemic fungal disease;
· Fungal infections of the skin and skin appendages (nails).
Mode of application:
Tablets Pimafucin
When intestinal candidiasis - 1 tablet 4 / day for adults, the course of treatment - 7 days. Children 1 tablet 2 p / day.
Candidiasis nails (in addition to applying the cream Pimafucin) - 1 tablet 4 / day, course of treatment 2-3 months.
Vulvovaginal candidiasis (in addition to intravaginal suppository Pimafucin for sanitation kandidomikoznoy focus of infection in the intestine) - 1 tablet 4 p / day treatment course of 10-20 days.
A common skin candidiasis (in addition to the use of local cream Pimafucin) - 1 tablet 4 / day, course of treatment - 7 days.
In onihomikozah (in addition to the use of local cream Pimafucin) - 1 tablet 4 / day, course of treatment - 2-3 months.
Suppositories Pimafucin
When vulvovaginal candidiasis - 1 suppository deep into the vagina 1 time a day at bedtime. Enter must be in a prone position. The duration of therapy is determined individually. The average course of treatment - 3-6 days. After the disappearance of the symptoms it is recommended to continue the intravaginal administration for 2-3 days.
Cream Pimafucin
When ringworm, candidiasis including nails or skin - put the cream on the affected area of the skin or nails from 1 to 4 p / day. The course of treatment - 2-3 weeks.
For the treatment of candidiasis lesions in the nature of sexual partner - applied to the anogenital area (as well as fungal diseases of the intestine, in addition to receiving the tablets Pimafucin).
Side effects:
When receiving natamycin tablets may diarrhea and nausea in the beginning of therapy, which disappear spontaneously during the further treatment.
When using natamycin topically (cream, suppository) may be a burning sensation and poorly marked irritation of the surrounding tissues.
Contraindications:
Hypersensitivity reactions to components pimafutsin.
Pregnancy:
Pimafucin not contraindicated for pregnant women, breastfeeding and newborn care.
Interaction with other drugs:
Not reveal any clinically significant interaction.
Overdose:
Due to the low absorption of overdose is unlikely.
Product:
Tablets coated with enteric coating. 100 mg of natamycin in one tablet. The contour package of 20 tablets.
Vaginal suppositories. 100 mg of natamycin in 1 suppositories. The cellular packaging 3 suppository.
Cream 2% in tubes of 30 g per 1 g of cream - 20 mg natamycin.
In addition:
Suppositories for intravaginal rapidly melt at body temperature, forming a bulk foaming mass - it improves the even distribution along the walls of the vagina of the active drug substance. In the case of chronic vulvovaginal candidiasis treatment is combined with taking pills or cream Pimafucin. In menstruating temporarily stop administering suppositories. The composition of suppositories include cetyl alcohol, which can cause allergic reactions. At the time of treatment suppositories Pimafucin exclude sex life is not necessary.
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