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Mode of action:
Cortexin - means a polypeptide with an optimal, balanced composition of polypeptides and neurotransmitters provider of tissue-specific effects on the cerebral cortex. The drug reduces the toxic effects of neurotrophic substances, improves learning ability of patients improves cognitive performance (nootropic effect), activates the repair processes in the central nervous system. Has also an anticonvulsant and cerebroprotective action. Cortexin contributes to the rapid restoration of the central nervous system after stress influences.
Cortexin normalizes the ratio of excitatory and inhibitory amino acids in the brain regulates dopamine and serotonin. Other mechanisms of action are the restoration of bioelectric activity of brain cells, the effect of oxidative stress (antioxidant effect) and GABAergic influence.
Pharmacokinetic parameters can not be determined because the L-amino acids and neuropeptides that are part of the drug had an average half-life of about 3 minutes, making it impossible to identify indicators of absorption, distribution and discretion peptide residues.
Indications for use:
· Neuroinfections (bacterial and viral in nature)
· The cerebral circulation,
· Traumatic brain injury,
· Encephalopathy of various etiologies,
· Asthenic syndrome,
· In the treatment of encephalitis and encephalomyelitis (acute and chronic forms)
· Epilepsy (in the complex therapy)
· Suprasegmental autonomic dysfunction,
· Impaired thinking, memory, decreased ability to learn,
· Cerebral palsy,
· Delayed speech and psychomotor development in children.
How to use:
It is intended for intramuscular administration. Content 1 vial dissolved before administration in 1-2 ml of solvent. The solvent may be water for injection or 0.9% sodium chloride or 0.5% solution of procaine. Enter 1 time per day for adults 10 mg rate 5-10 days. In pediatrics: children weighing more than 20 kg - adult dosage for children up to 20 kg (can be used with the first days of life) - 1 5 mg once a day. The course of treatment - 5-10 days. If necessary, the course cortexin injections can be repeated after 1-6 months.
Side effects:
Possible hypersensitivity reactions (rare).
Contraindications:
In case of indications of a history of allergic reactions to cortexin and other ingredients.
Pregnancy:
During pregnancy, as well as breastfeeding is contraindicated.
Interactions with other drugs:
It is used in the treatment. There were no reports of adverse interactions.
Overdose:
The clinical picture of overdosage cortexin not described.
Product:
The lyophilized powder in vials of 10 mg. Designed for solution for intramuscular administration.
Storage:
In a place protected from moisture at temperatures 2-10 ° C.
Ingredients:
Active ingredient: cortexin.
Other glycine.
In addition:
The drug has no effect on psychomotor reaction, so it can be assigned to drivers and those working with complex technology.
